The Chemokine SDF - 1 Is a Chemoattractant for Human CD 34 1 Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD 34 1 Progenitors to Peripheral Blood
نویسنده
چکیده
Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stromal cells. This is the first chemoattractant reported for human CD34 1 progenitor cells. Concentrations of SDF-1 that elicit chemotaxis also induce a transient elevation of cytoplasmic calcium in CD34 1 cells. SDF-1-induced chemotaxis is inhibited by pertussis toxin, suggesting that its signaling in CD34 1 cells is mediated by seven transmembrane receptors coupled to G i proteins. CD34 1 cells migrating to SDF-1 include cells with a more primitive (CD34 1 /CD38 2 or CD34 1 /DR 2 ) phenotype as well as CD34 1 cells phenotypically committed to the erythroid, lymphoid and myeloid lineages, including functional BFU-E, CFU-GM, and CFU-MIX progenitors. Chemotaxis of CD34 1
منابع مشابه
The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood
Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stromal cells. This is the first chemoattractant reported for human CD34+ progenitor cells. Concentrations of SDF-1 that elicit chemotaxis also induce a transient elevation of cytoplasmic calcium in CD34+ cells. SDF-1-induced chemotaxis is in...
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